Tight end Julius Thomas, who leads the NFL with 12 touchdown catches this season, left in the first quarter with a sprained ankle and was later ruled out. He’ll undergo an MRI on Monday.
MORE: Emmanuel Sanders takes brutal hit | Week 11 picks | Scores, updates
Running back Montee Ball also was questionable after aggravating a groin injury that sidelined him for five games. Ball was injured in the first quarter, briefly returned and dropped a pass, and then was downgraded to questionable.
The Rams opened up a 13-0 lead over the favored Broncos before Manning hit Emmanuel Sanders with a big touchdown strike right before halftime.
Sanders in the third quarter took a brutal hit and was ruled out with a concussion, so Manning is down three key weapons.
